Dr. Alessandro Fichera received his medical degree from Catholic University of Rome, Italy in 1989 as a Magna cum Laude graduate and completed his internship and residency in general surgery at the 2nd University of Rome and then again at the University of Chicago followed by fellowship training in colorectal surgery at Mt. Sinai in New York. He accepted an Assistant Professor position the University of Chicago in 2002 and became the Program Director for the Colon and Rectal Surgery Residency Training Program. In 2012, Dr. Fichera accepted a position as Professor at the University of Washington. In 2014, Dr. Fichera was named Section Chief of Gastrointestinal Surgery and in 2015 he became the Clinical Director for the Gastrointestinal Oncology Program for the Seattle Cancer Care Alliance and Associate Medical Director for Colorectal, Surgical Care and Outcomes Assessment Program as part of the Foundation for Health Care Quality.

In November 2017 he moved to University of North Carolina as the Division Chief of Gastrointestinal Surgery. In September 2019 he moved to Baylor University Medical Center in Dallas, Texas where he was the Division Chief of Colorectal Surgery, President Elect of the Medical Staff and the Surgery Safety and Quality Officer. He was the NSQIP and ERAS surgeon champion and the co-director of the NAPRC accredited Rectal Cancer Program. He serves on the ASCRS Executive Council and the Crohn's and Colitis Foundation National Scientific Advisory Committee