Charles G Drake, MD, PHD

Dr. Charles G. Drake is a physician-scientist with a Ph.D. in immunology, whose work focuses on understanding and fighting advanced-stage cancers with the immune system. He is known for rapidly incorporating discoveries made in the research lab into innovative clinical trials, including anti-tumor vaccines.

The Drake laboratory was the first group to show that LymphocyteActivation Gene–3 (LAG-3) is a cell surface marker for CD4 cells with regulatory function (Treg) and that blockade of LAG-3 with a monoclonal antibody could restore anti-tumor immune responses by mitigating CD8 T-cell tolerance in vivo. Further work demonstrated that LAG-3 and PD-1 were co-expressed on funct...