Dr. Noble completed his undergraduate studies in math and chemistry at Vanderbilt University, followed by medical school at Emory University. His graduate medical training included internal medicine internship, neurology residency including chief resident in neurology, and neuroepidemiology and behavioral neurology fellowship, all at Columbia University Irving Medical Center. Accordingly, he is board certified in neurology, behavioral neurology & neuropsychiatry, and public health.

Dr. Noble primarily sees patients with dementia but is also involved in multidisciplinary clinical and research efforts to support patients with persistent post-concussive symptoms. Dr. Noble is fluent in Spanish and his comprehensive approach to care views the patient within the entire family dynamic, with particular focus on disadvantaged communities.

Dr. Noble is also a recognized neurologic educator at Columbia University Vagelos College of Physicians & Surgeons, having held leadership positions as a current or former lead of its neurology clerkship, preclinical neuroscience training and summer research training programs. He has received an AAN A.B. Baker Teacher Recognition Award and is a scholar in Columbia's Virginia Apgar Teaching Academy. Aside from his clinical work and commitment to neurologic education, Dr. Noble directs and supports several longitudinal NIH-supported research initiatives related to Columbia's Alzheimer's Disease Research Center, all of which aim to identify novel lifecourse modifiable risk factors for cognitive aging and means to improve public health literacy.

His professional leadership has been recognized by the American Academy of Neurology (AAN). He was an inaugural member of the AAN Emerging Leaders Program and is a Fellow of the AAN. He is the co-editor of the 14th edition of Merritt's Neurology, a standard global neurology textbook. He is the author of Navigating Life with Dementia, a handbook for dementia caregivers. Dr. Noble co-founded Arts & Minds, a non-profit organization promoting well-being for dementia patients and their caregivers via art-centered experiences, as well as NoMo Diagnostics, which aims to better diagnose concussion with technology Dr. Noble and others developed at Columbia University.