Dr. Sanfilippo is a radiation oncologist with special interest in treatment of head and neck, thoracic, cutaneous, and genitourinary malignancies. He received his undergraduate and medical degrees from the University of Virginia and completed his residency training in radiation oncology at the University of Pennsylvania. He then spent an additional year of training in brachytherapy at the Gustave-Roussy Institute in Villejuif, France. Following a short time in private practice, Dr. Sanfilippo joined the faculty at New York University School of Medicine where he was a member of the disease management groups in head and neck, genitourinary, and melanoma services. He also served as Clinical Medical Director and later Vice Chair for Clinical Operations in the Department of Radiation Oncology. He was promoted to Associate Professor of Radiation Oncology in 2014.

Dr. Sanfilippo has authored numerous original reports, reviews, and textbook chapters. He is also co-authoring a textbook on intensity modulated radiation therapy. He has received numerous research grants from both private and public entities including the National Institutes of Health. Dr. Sanfilippo joined Weill Cornell Medicine in 2018 as Vice Chair of the Department of Radiation Oncology, Residency Program Director, and Director of Quality Assurance.