Ype de Jong studied medicine at the University of Amsterdam Medical School. After completing his master's in Amsterdam he conducted research into the immunopathogenesis of Crohn's disease at the Beth Israel Deaconess Medical Center in Boston, with which he obtained his PhD. He subsequently completed his Internal Medicine internship and residency at the Mount Sinai Hospital in New York, followed by a fellowship in Gastroenterology at the same institution. He currently is an Assistant Professor of Medicine at Weill-Cornell Medical College. Dr de Jong is an intricate part of the Center for the Study of Hepatitis C, both as a physician at New York-Presbyterian Hospital and as a Visiting Clinical Fellow at The Rockefeller University.